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Taxonomic Coverage Across Databases

This document describes what organisms and clades are covered by different databases in the JGI and KBase lakehouses.

Overview

Database Scope Organisms Focus
GOLD Universal 598K All sequenced organisms (registry)
IMG Microbial 287K Annotated microbial genomes
KBase Pangenome Bacteria/Archaea 293K GTDB-classified prokaryotes
MycoCosm Fungi ~2,500 Fungal comparative genomics
Phytozome Plants ~250 Plant comparative genomics
IMG/VR Viruses 22K+ Viral sequences

Data Types

Databases contain a mix of:

Type Description GOLD Count
Isolate genomes Cultured organisms 518K (87%)
MAGs Metagenome-assembled genomes 79K
SAGs Single-cell amplified genomes 16K
Metagenomes Community DNA 223K projects
Metatranscriptomes Community RNA 40K projects

GOLD: The Genome Registry

GOLD (Genomes OnLine Database) tracks all sequencing projects at JGI and beyond.

Domain Distribution

Domain Organisms Percentage
Bacteria 489,957 81.9%
Eukarya 69,683 11.6%
Viruses 17,496 2.9%
Archaea 6,877 1.2%
Unknown 14,048 2.4%

Bacterial Coverage

Top phyla (using modern nomenclature):

Phylum Count % of Bacteria
Pseudomonadota (Proteobacteria) 211,920 43%
Bacillota (Firmicutes) 139,789 29%
Actinomycetota (Actinobacteria) 70,898 14%
Bacteroidota 23,577 5%
Campylobacterota 11,079 2%
Cyanobacteriota 4,828 1%

Top genera:

Genus Count Notes
Pseudomonas 24,177 Environmental/clinical
Escherichia 22,452 Model organism, pathogens
Streptococcus 22,083 Human pathogens
Staphylococcus 19,825 Human pathogens
Salmonella 16,301 Food safety
Bacillus 12,960 Industrial/environmental
Streptomyces 12,156 Natural products

Bias note: Clinical and industrially-relevant genera are overrepresented.

Archaeal Coverage

Kingdom Count Notes
Methanobacteriati 4,358 Methanogens
Thermoproteati 1,709 Thermophiles
Other ~800 Various

Archaea are underrepresented (1.2%) with roughly equal cultured/uncultured split, unlike bacteria where cultured dominates.

Eukaryotic Coverage

Kingdom Count Notes
Viridiplantae 40,978 Plants (→ Phytozome)
Fungi 21,298 Fungi (→ MycoCosm)
Metazoa 4,934 Animals
Other protists ~2,500 Various

Viral Coverage

Realm Count Notes
Orthornavirae 5,255 RNA viruses
Shotokuvirae 2,750 dsDNA viruses (phages)
Other ~9,500 Various

Metagenomes and Environmental Samples

Cultured vs Uncultured

Status Count Percentage
Cultured 518,241 86.7%
Uncultured 79,815 13.3%

Uncultured breakdown:

Type Count Description
Metagenomic 63,270 Binned from metagenomes
Single Cell 15,962 SAGs
Other ~600 Enrichments, pooled

Project Types

Project Type Count
Genome Analysis (Isolate) 286,643
Metagenome Analysis 152,545
Metagenome-Assembled Genome 78,813
Metatranscriptome Analysis 29,309
Single Cell Analysis 14,741

Ecosystem Classification

GOLD uses a hierarchical ecosystem classification:

Ecosystem (top level)
  └── Ecosystem Category
        └── Ecosystem Type
              └── Ecosystem Subtype
                    └── Specific Ecosystem

Top-Level Ecosystems

Ecosystem Count Examples
Host-associated 153,878 Human gut, plant roots
Environmental 80,581 Soil, ocean, freshwater
Engineered 22,261 Bioreactors, wastewater

Host-Associated Breakdown

Category Count Notes
Human 85,157 55% of host-associated
Other Mammals 21,477 Livestock, wildlife
Plants 22,816 Rhizosphere, phyllosphere
Birds 4,804 Poultry, wildlife
Insects 3,268 Pollinators, pests

Human body sites:

Site Count
Digestive system 34,767
Respiratory system 14,679
Circulatory system 7,645
Skin ~5,000
Oral cavity ~4,000

Environmental Breakdown

Type Count Examples
Soil 31,563 Forest, agricultural, permafrost
Marine 19,527 Pelagic, sediment, hydrothermal
Freshwater 7,101 Lakes, rivers, wetlands
Other ~22,000 Air, rock, ice

Special categories: - "Plant-associated metagenome" → Host-associated > Plants - "Soil metagenome" → Environmental > Terrestrial > Soil - "Human gut metagenome" → Host-associated > Human > Digestive system

IMG: Annotated Microbial Genomes

IMG focuses on microbial genomes with comprehensive functional annotation.

Total taxa: 286,758

Domain Distribution

Domain Count Percentage
Bacteria 167,336 58.5%
*Microbiome 90,371 31.6%
Viruses 21,818 7.6%
Archaea 4,536 1.6%
Eukaryota 1,192 0.4%
Plasmids ~1,200 0.4%

Note: "*Microbiome" entries are metagenomic assemblies, not isolate genomes.

Genome Types

IMG distinguishes: - Isolate - Single organism genomes (~173K) - Metagenome - Community assemblies (~90K) - Plasmids - Mobile elements - Genome Fragments - Partial sequences

KBase Pangenome: GTDB-Classified Prokaryotes

The KBase pangenome database contains 293,059 bacterial and archaeal genomes classified using GTDB (Genome Taxonomy Database).

Coverage

Domain Genomes Species Clades
Bacteria ~280K ~80K
Archaea ~13K ~5K

GTDB vs NCBI Taxonomy

GTDB provides standardized, rank-normalized taxonomy that often differs from NCBI:

NCBI Name GTDB Name Notes
Proteobacteria Pseudomonadota Renamed
Firmicutes Bacillota Renamed
"Candidatus X" X Standardized

MycoCosm: Fungal Genomes

JGI's fungal genome portal with ~2,500+ genomes across three MySQL servers.

Taxonomic Coverage

Phylum Genomes Examples
Ascomycota ~1,500 Aspergillus, Neurospora, yeasts
Basidiomycota ~800 Agaricus, Coprinopsis, Laccaria
Mucoromycota ~100 Mucor, Rhizopus
Chytridiomycota ~50 Batrachochytrium
Other ~50 Microsporidia, etc.

Database Structure

Each fungal genome has its own schema in Dremio: - myco-db-1 mysql.Aspni7 (Aspergillus niger) - myco-db-1 mysql.Copci1 (Coprinopsis cinerea) - myco-db-2 mysql.Lacbi2 (Laccaria bicolor)

Tables per genome: 100-250, including:

Table Description
FilteredModels1 Curated gene models (primary gene set)
GeneCatalog1 Gene catalog entries
InterPro1 InterPro domain annotations
blastp1 BLASTP hits
SM_cluster1 Secondary metabolite clusters
KOG1 KOG functional categories

Naming Convention

Genome schema names follow pattern: {Genus3}{species3}{version} - Aspni7 = Aspergillus niger v7 - Copci1 = Coprinopsis cinerea v1 - Agabi_varbisH97_2 = Agaricus bisporus var. bisporus H97 v2

Phytozome: Plant Genomes

JGI's plant comparative genomics portal using GMOD Chado schema.

Database: plant-db-7 postgresql.public (306 tables)

Coverage

Clade Genomes Examples
Angiosperms ~200 Arabidopsis, rice, maize, soybean
Gymnosperms ~10 Pine, spruce
Ferns/Lycophytes ~5 Selaginella
Bryophytes ~10 Physcomitrella, Marchantia
Algae ~30 Chlamydomonas, Volvox, Ostreococcus

Database Structure

Unlike MycoCosm (schema-per-genome), Phytozome uses a unified Chado schema:

Table Description
feature All genomic features (genes, mRNAs, exons)
featureloc Feature coordinates
organism Species metadata
analysis Annotation pipeline metadata
featureprop Feature properties/attributes

Key Features

  • Gene family clustering across all plant genomes
  • Expression atlas data
  • Synteny and whole-genome duplication analysis
  • PFAM/InterPro domain annotations

IMG/VR: Viral Genomes

Database: img-db-1 mysql.imgvr_prod

Total UViGs: 15.7 million viral sequences

Sources

Source Count Description
Metagenome 14.2M (90.6%) Predicted from metagenomes
Metatranscriptome 1.2M (7.3%) RNA viruses from metatranscriptomes
Isolate 294K (1.9%) Cultured phages and viruses
RefSeq 14K Curated reference sequences
MAG 13.5K From metagenome-assembled genomes
SAG 1.6K Single amplified genomes

Viral Realm Distribution

Realm Count Description
Duplodnaviria 13.5M (86%) dsDNA viruses (mostly bacteriophages)
Varidnaviria 1.0M (6.7%) Large/giant DNA viruses
Riboviria 531K (3.4%) RNA viruses
Unclassified 521K (3.3%) No realm assigned
Monodnaviria 72K (0.5%) ssDNA viruses
Adnaviria 3.7K Archaeal filamentous viruses

Key Tables

Table Rows Description
uvig 15.7M Main viral sequences
uvig_lineage 15.7M ICTV taxonomy
uvig_hosts 1.1M Predicted hosts
uvig_domain 118.7M Protein domains
uvig_pfams 50.4M PFAM annotations

Cross-Database Organism Lookup

By NCBI Taxonomy ID

Most databases link via NCBI taxonomy:

-- Find organism across databases
SELECT 'GOLD' as db, organism_name
FROM "gold-db-2 postgresql".gold.organism_v2
WHERE ncbi_taxon_id = 562  -- E. coli

UNION ALL

SELECT 'IMG' as db, taxon_display_name
FROM "img-db-2 postgresql".img_core_v400.taxon
WHERE ncbi_taxon_id = 562

By Assembly Accession

For genome-level matching:

-- Match KBase to GOLD via assembly accession
SELECT kb.genome_id, gold.organism_name
FROM kbase_ke_pangenome.genome kb
JOIN "gold-db-2 postgresql".gold.ncbi_assembly gold
    ON SUBSTRING(kb.genome_id FROM 4) = gold.assembly_accession

Coverage Gaps and Biases

Overrepresented

Category Reason
Human pathogens Clinical relevance, surveillance
Model organisms Research investment
Industrial microbes Biotechnology applications
Human gut microbiome Health research funding

Underrepresented

Category Reason
Environmental Archaea Difficult to culture
Deep-sea organisms Sampling challenges
Protists Genome complexity
Non-human host microbiomes Less funding
Rare biosphere Low abundance

Data Type Biases

Bias Impact
Isolate bias (87%) Missing unculturable diversity
Short-read assemblies Fragmented genomes, missing repeats
Reference genome focus Strain diversity undersampled

Recommendations

  1. For prokaryotic diversity: Use KBase pangenome with GTDB taxonomy
  2. For metagenome context: Use GOLD ecosystem classification
  3. For fungi: Use MycoCosm (clade-specific annotations)
  4. For plants: Use Phytozome (clade-specific annotations)
  5. For viruses: Use IMG/VR
  6. For cross-database queries: Join on NCBI taxonomy ID or assembly accession

Key Tables

GOLD

Table Description
organism_v2 Organism metadata with taxonomy
project Sequencing project metadata
ncbi_taxonomy Full NCBI taxonomy
ncbi_assembly Assembly accessions

IMG

Table Description
taxon Genome metadata
taxon_stats Genome statistics

KBase

Table Description
genome GTDB-classified genomes
gtdb_species_clade Species-level groupings