Figure: F13a1 and F13b-mouse-blood clotting¶
This illustration depicts the F13a1 and F13b mouse blood clotting pathway in the style of a journal figure. The diagram shows three key proteins:
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F2 (MGI:88380): A serine-type endopeptidase that both positively regulates F13a1 and negatively regulates F13b.
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F13b (MGI:88379): A protein with binding activity that negatively regulates F13a1.
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F13a1 (MGI:1921395): A protein-glutamine gamma-glutamyltransferase that plays a crucial role in blood coagulation and fibrin clot formation.
The interactions between these proteins are depicted with color-coded arrows - green for positive regulation and red for negative regulation. F2 activates F13a1 while inhibiting F13b, and F13b inhibits F13a1. The pathway ultimately leads to blood coagulation and fibrin clot formation, represented by the pink box at the bottom of the diagram.
The background represents blood plasma where these interactions take place.
Feedback from AI on figure:
{"feedback":"The diagram successfully illustrates the GO-CAM model of F13a1 and F13b-mouse-blood clotting in a clear, journal-worthy manner. The representation includes all key proteins (F2, F13b, F13a1) and their relationships, with appropriate visual differentiation through colors and shapes. The regulatory relationships (positive and negative) are clearly indicated with color-coded arrows, and the addition of a legend enhances understanding. The simple explanations of technical terms (e.g., 'protein cutting enzyme' for serine-type endopeptidase) make the diagram accessible while maintaining scientific accuracy. The final outcome of blood coagulation and fibrin clot formation is prominently displayed, emphasizing the pathway's biological significance.","necessary_changes":null,"optional_changes":null}