Figure: IL1beta-mediated signaling pathway (Human)¶
This diagram depicts the IL1β-mediated signaling pathway in human cells. The pathway is shown as a sequential activation cascade from the extracellular space through the plasma membrane into the cytoplasm.
Key components: - IL1B (P01584): A cytokine in the extracellular region that initiates the signaling - CASP1 (P29466): A cysteine protease in the cytosol that processes and activates IL1B - IL1R1 (P14778): The primary IL1B receptor on the plasma membrane - IL1RAP (Q9NPH3): A co-receptor that associates with IL1R1 upon IL1B binding - TOLLIP (Q9H0E2): An adaptor protein that regulates the signaling pathway - MYD88 (Q99836): An adaptor protein that facilitates signal transduction - IRAK4 (Q9NWZ3): A kinase that initiates the phosphorylation cascade - IRAK1 (P51617): A kinase activated by IRAK4 that continues signal propagation - MAP3K7 (O43318): A downstream kinase that leads to further cellular responses
The arrows indicate activation relationships between proteins in the pathway, showing how the signal is transmitted from the extracellular cytokine through membrane receptors to intracellular kinases.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the IL1β-mediated signaling pathway with clear hierarchical organization and visual distinction between different cellular compartments. The use of different shapes and colors for various protein types (cytokines, receptors, adaptors, and kinases) enhances comprehension of their functional roles. Each component is clearly labeled with both the protein name and UniProt ID, and includes a brief functional annotation that aids understanding.\n\nThe pathway flow is logically presented from extracellular signaling through receptor binding to downstream kinase activation, with clearly labeled arrows indicating the relationships between components. The cellular compartmentalization (extracellular region, plasma membrane, cytoplasm, and cytosol) provides important spatial context for the signaling events.\n\nThe enlarged text size, bold formatting for function annotations, and addition of a 'Protease' category in the legend further improve clarity and readability, making this diagram suitable for publication in high-impact scientific journals.","necessary_changes":null,"optional_changes":null}