Figure: Regulation of sprouting angiogenesis via dll4, egfl6, itgb1a (D. rerio)¶
This diagram illustrates the molecular pathway regulating sprouting angiogenesis in zebrafish (Danio rerio), based on the GO-CAM model. The pathway involves three key proteins: EGFL6, ITGB1A, and DLL4.
EGFL6 is expressed in somite cells and functions as both a receptor ligand and integrin-binding protein. When secreted, EGFL6 binds to ITGB1A receptors on endothelial tip cells. This binding activates ITGB1A's signaling receptor activity, which subsequently activates DLL4. DLL4, with its Notch binding capability, initiates the Notch signaling pathway, ultimately resulting in the positive regulation of sprouting angiogenesis.
The diagram uses distinct colors to represent different components: proteins (red/pink), cells (blue/green), molecular functions (orange), and biological processes (light green). All identifiers from the ontologies (GO, ZFA, CL, RO, ZFIN) are included to provide precise annotation of the pathway components.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the regulation of sprouting angiogenesis in zebrafish with exceptional clarity and scientific precision. The pathway from EGFL6 in somite cells through ITGB1A receptors on endothelial cells to DLL4 and the Notch signaling pathway is depicted with clear directional flow. The inclusion of specific ontology IDs (GO, ZFA, CL, RO) and gene identifiers makes this suitable for a scientific publication, while the color-coding and visual organization help readers quickly understand the relationships between components. The expanded legend explaining identifier prefixes is particularly helpful for readers who may not be familiar with all notation systems used in molecular biology.","necessary_changes":null,"optional_changes":null}