Figure: Mouse-Aatf-antiapoptosis¶
This illustration depicts the Mouse-Aatf-antiapoptosis pathway in Type B pancreatic cells (CL:0000169), focusing on the endoplasmic reticulum unfolded protein response (GO:0030968) pathway that ultimately leads to negative regulation of intrinsic apoptotic signaling (GO:2001243).
The pathway begins with Xbp1 activating Wfs1, while in parallel, Eif2ak3 activates Eif2a, which inhibits the Aatf/Stat3 transcription regulator complex (GO:0005667). Wfs1 and Ern1 both activate this complex, which in turn positively regulates Akt1 and also activates another instance of Wfs1. Akt1 ultimately leads to negative regulation of the intrinsic apoptotic signaling pathway.
The diagram uses different arrow styles to distinguish interaction types: solid lines for activation (RO:0002304), dashed lines for inhibition (RO:0004047), and blue arrows for positive regulation (RO:0002629). Cellular compartments (nucleus, endoplasmic reticulum) are shown to represent the spatial organization of these molecular interactions.
Feedback from AI on figure:
{"feedback":"This diagram effectively represents the Mouse-Aatf-antiapoptosis GO-CAM model with clarity and scientific accuracy. The key strengths include:\n \n 1. Clear spatial organization showing cellular compartments (ER, nucleus, cytoplasm) with appropriate gene product localization\n 2. Distinct visual encoding of different interaction types using both color and line styles\n 3. Comprehensive legend that explains all visual elements\n 4. Proper representation of the protein complex (Aatf/Stat3) and its regulatory role\n 5. Clear pathway progression from initial stimuli to the biological outcome (negative regulation of apoptotic signaling)\n \n The illustration balances scientific detail with visual clarity, making it suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}