Figure: dAMP catabolic process to allantoin (Mouse)¶
This scientific illustration depicts the dAMP catabolic process to allantoin in mouse cells, as described in the GO-CAM model. The pathway begins in the cytosol with dAMP and proceeds through several enzymatic steps before ending with allantoin production in the peroxisome.
Key components: - Red circles: Metabolites (dAMP, dAdo, dIno, Hx, Xan, Urate, HIU, OHCU, Allantoin) - Green rectangles: Enzymes (Nt5c1a, Ada, Pnp, Xdh, Uox, Urah, Urad) - Yellow rectangle: Implicit transport process (not explicitly defined in the GO-CAM) - Dashed line: Implicit transport step (not explicitly defined in the GO-CAM)
Metabolite abbreviations: - dAMP: 2'-deoxyadenosine 5'-monophosphate - dAdo: 2'-deoxyadenosine - dIno: 2'-deoxyinosine - Hx: hypoxanthine - Xan: xanthine - HIU: 5-hydroxyisourate - OHCU: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
The pathway represents a series of enzymatic reactions that occur in two cellular compartments: 1. Cytosol (GO:0005829): Initial degradation steps from dAMP to urate 2. Peroxisome (GO:0005777): Final conversion steps from urate to allantoin
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the dAMP catabolic process to allantoin in mouse cells as described in the GO-CAM model. The pathway is presented in a clear, scientifically accurate manner suitable for publication in a high-tier journal like Cell or Nature. The diagram successfully represents the compartmentalization of the process between the cytosol and peroxisome, with appropriate enzyme placement and metabolite progression. The use of color coding helps distinguish between different components (enzymes, metabolites, and implicit processes), and the inclusion of full chemical names enhances the educational value of the figure. The implicit transport step between compartments is appropriately marked as not being explicitly defined in the source data.","necessary_changes":null,"optional_changes":null}