Figure: IMP catabolic process to allantoin (Mouse)

id: gomodel:5fa76ad400000374

The diagram depicts the IMP catabolic pathway in mouse cells, showing the enzymatic conversion of IMP to allantoin.

The pathway begins in the cytosol with IMP being processed by three different enzymes (Nt5c, Nt5c2, and Nt5c1a) that possess IMP 5'-nucleotidase activity. This produces hypoxanthine, which is then oxidized by Xanthine dehydrogenase/oxidase (Xdh) to xanthine, and further to urate, still within the cytosol.

Urate is then transported to the peroxisome (shown as a dashed line), where it undergoes a series of enzymatic conversions: Urate oxidase (Uox) converts urate to 5-hydroxyisourate (5-HIU), which is then processed by Hydroxyisourate hydrolase (Urah) to form 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Finally, OHCU decarboxylase (Urad) converts OHCU to allantoin, the end product of the pathway.

Metabolites are represented as circles, enzymes as rectangles, and implicit intermediates (not explicitly mentioned in the source GO-CAM) are indicated. The pathway spans two cellular compartments: the cytosol and the peroxisome, with different enzymatic reactions occurring in each compartment.

Feedback from AI on figure:

{"feedback":"The final diagram effectively illustrates the IMP catabolic process to allantoin in mouse cells. It clearly shows the pathway progression through two cellular compartments (cytosol and peroxisome) with appropriate enzyme and metabolite representations. The inclusion of reaction labels and a comprehensive legend enhances understanding of the biological process.","necessary_changes":null,"optional_changes":null}