Figure: Fzd3 function in Cranial neural crest cells¶
This figure illustrates the Fzd3 function in cranial neural crest cells based on the GO-CAM model. The diagram shows a cell with its extracellular region, cell membrane, cytosol, and nucleus. The pathway depicts how Wnt ligands (Wnt4, Wnt11) interact with Frizzled receptors (Fzd3, Fzd7) and co-receptor PTK7 at the cell membrane. These interactions trigger signaling through Dvl1, which activates small GTPases RhoA and Rac1. RhoA activates ROCK1, while Rac1 activates JNK, with Chn1 acting as a negative regulator of Rac1. These signaling events ultimately regulate planar cell polarity (PCP) pathway and cell migration in cranial neural crest cells. Nuclear proteins tp53 and pes1 are also shown as part of this regulatory network.
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively illustrates the Fzd3 function in cranial neural crest cells with excellent clarity and scientific accuracy. The cellular compartments are clearly delineated with distinct boundaries and appropriate labels, including GO IDs for reference. The molecular components are well-organized with sufficient spacing, preventing visual clutter. The color-coding system differentiates between different types of proteins and cellular processes, making the diagram easy to interpret. The improved arrow coloring (blue for binding, green for activation, red for inhibition) enhances the readability of the signaling flow. The diagram successfully captures the key elements of Wnt signaling through Frizzled receptors and the downstream effects via RhoA and Rac1 pathways, leading to cell migration and PCP pathway activation in cranial neural crest cells.","necessary_changes":null,"optional_changes":null}