Figure: UMP catabolic process (Mouse)¶
The diagram illustrates the UMP catabolic process in mouse cells, visualizing a GO-CAM (Gene Ontology Causal Activity Model) as a metabolic pathway. The process begins in the cytosol with UMP and proceeds through several enzymatic steps until β-alanine is produced, which is then transported to the mitochondria for further metabolism.
Key components represented: - Metabolites: UMP → Uridine → Uracil → Dihydrouracil → N-carbamoyl-β-alanine → β-alanine - Enzymes involved (mouse gene products): * 5'-nucleotidases (Nt5c3, Nt5c) - catalyze conversion of UMP to uridine * Uridine phosphorylases (Upp1, Upp2) - convert uridine to uracil * Dihydropyrimidine dehydrogenase (Dpyd) - transforms uracil to dihydrouracil * Dihydropyrimidinase (Dpys) - converts dihydrouracil to N-carbamoyl-β-alanine * β-ureidopropionase (Upb1) - produces β-alanine from N-carbamoyl-β-alanine * β-alanine:pyruvate transaminase (Agxt2) - located in mitochondria, metabolizes β-alanine further
All reactions depicted in the cytosol occur in the GO:0005829 compartment, while the final reaction with Agxt2 takes place in the mitochondrion (GO:0005739). The entire process corresponds to the GO biological process "UMP catabolic process" (GO:0046050).
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the UMP catabolic process in mouse cells with excellent clarity and scientific precision. The pathway is represented clearly, showing the progression from UMP through various intermediates to β-alanine, with correct subcellular localization in the cytosol and mitochondria. The enzymes catalyzing each step are accurately labeled with both their functions and gene symbols, making the diagram informative for scientific audiences.","necessary_changes":null,"optional_changes":null}