Figure: dUMP catabolic process (Mouse)¶
This figure illustrates the dUMP catabolic process in mouse cells as represented in GO-CAM model 5fadbcf000000868. The pathway shows the sequential enzymatic reactions primarily occurring in the cytosol, with one enzyme (Agxt2) acting in the mitochondrion.
The metabolic pathway begins with dUMP, which is converted to deoxyuridine (dUrd) by either Nt5c or Nt5c3 (5'-nucleotidase activity, GO:0008253). Deoxyuridine is then converted to uracil by Upp1 (deoxyuridine phosphorylase activity, GO:0047847). Uracil undergoes further transformation to dihydrouracil (DHU) via Dpyd (dihydropyrimidine dehydrogenase activity, GO:0017113). Dpys (dihydropyrimidinase, GO:0004157) then converts dihydrouracil to β-ureidopropionate, which is processed by Upb1 (beta-ureidopropionase, GO:0003837) to form β-alanine. In the mitochondrion, Agxt2 (beta-alanine:pyruvate transaminase, GO:0016223) further metabolizes β-alanine.
The diagram uses consistent colors and shapes to distinguish between cytosolic enzymes (blue ellipses) and mitochondrial enzymes (orange ellipse). Solid arrows represent metabolic flow, while dashed lines indicate enzyme actions on substrates.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the dUMP catabolic pathway in mouse cells, showing a clear progression of metabolites through various enzymatic transformations. The visual representation distinguishes between cytosolic and mitochondrial compartments, with appropriate colors and shapes to indicate different components. The use of consistent arrow styling helps differentiate between metabolic flow and enzyme actions, enhancing the clarity of the biological process being depicted. The inclusion of GO terms for each enzyme activity provides valuable reference information, making this suitable for a scientific publication in journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}