Figure: dTMP catabolic process (Mouse)¶
This diagram depicts the dTMP catabolic process in mouse cells (GO:0046074), illustrating how deoxythymidine monophosphate (dTMP) is broken down through a series of enzymatic reactions. The pathway begins in the cytosol (GO:0005829) with the conversion of dTMP to thymidine by 5'-nucleotidases (Nt5c and Nt5c3). Thymidine is then converted to thymine by thymidine phosphorylases (Tymp and Upp1), which is subsequently converted to dihydrothymine by dihydropyrimidine dehydrogenase (Dpyd). Dihydropyrimidinase (Dpys) then converts dihydrothymine to N-carbamoyl-β-alanine, which is further converted to β-alanine by β-ureidopropionase (Upb1). The final step occurs in the mitochondrion (GO:0005739), where β-alanine is converted to malonate semialdehyde by the transaminase Agxt2. Each enzyme is shown with its corresponding GO molecular function term, and the arrows indicate the direction of the catabolic process.
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{"feedback":"This diagram effectively illustrates the dTMP catabolic pathway in mouse cells with excellent clarity and scientific accuracy. The layout follows professional standards suitable for publication in high-impact journals like Cell or Nature. The cellular compartmentalization is clearly depicted, with the majority of reactions occurring in the cytosol and the final step in the mitochondrion. Each enzyme and metabolite is properly labeled, with appropriate GO term annotations. The flow of the pathway is intuitive and easy to follow with prominent arrows. The inclusion of a detailed legend and abbreviations section enhances understanding for readers with varying levels of familiarity with the subject matter.","necessary_changes":null,"optional_changes":null}