Figure: SPModule IFIH1-MAVS¶
This pathway diagram illustrates the IFIH1-MAVS signaling pathway based on the GO-CAM model. In the cellular cytoplasm, the retinoic acid-inducible gene I (RIG-I)-like receptor IFIH1 (Q9BYX4) recognizes viral double-stranded RNA (dsRNA), triggering a signaling cascade. Upon dsRNA recognition (GO:0038187), IFIH1 activates the phosphatase PPP1CA (P62136), which in turn positively regulates IFIH1 through its phosphatase activity (GO:0016791). The activated IFIH1, in association with ATP, undergoes a conformational change enabling protein-protein interaction (GO:0042802) with MAVS (Q7Z434) located on the mitochondrial outer membrane. This interaction leads to MAVS oligomerization and activation of its signaling adaptor function (GO:0035591), which initiates downstream antiviral responses. The pathway represents a critical part of the innate immune response to viral infection.
Feedback from AI on figure:
{"feedback":"This SVG drawing effectively depicts the IFIH1-MAVS signaling pathway in a clear and scientifically accurate manner suitable for publication in high-tier journals. The diagram presents a logical flow from viral dsRNA recognition through the activation cascade to MAVS signaling, with appropriate cellular compartmentalization shown between cytoplasm and mitochondria. The use of distinct colors for different components enhances readability while maintaining a professional aesthetic.","necessary_changes":null,"optional_changes":"Future iterations could include downstream signaling events or incorporate more detailed structural representations of the proteins involved. Additionally, the diagram could be enhanced with brief explanations of the biological significance of each step in the pathway."}