Figure: SP_SIK2-actvity-on-P300

id: gomodel:5fadbcf000001646

This diagram illustrates the SIK2-P300 pathway that regulates lipid biosynthesis in liver cells.

Within the chromatin environment: - SIK2 (Q9H0K1) inhibits EP300 (Q09472) through its protein serine/threonine kinase activity - EP300 activates MLXIPL (Q9NP71) via its acetyltransferase activity - EP300 also activates PPARA (Q07869) through protein binding - MLXIPL promotes lipid biosynthesis through its DNA-binding transcription activator activity - PPARA functions as a DNA-binding transcription activator

The diagram uses color-coding to distinguish different proteins and clearly marked arrows to indicate activation (green) and inhibition (red) relationships between pathway components.

Feedback from AI on figure:

{"feedback":"This diagram effectively represents the GO-CAM pathway showing the SIK2-P300 regulation of lipid biosynthesis in liver cells. The visualization places all interactions within the appropriate cellular context (liver cell nucleus, specifically in chromatin) and clearly depicts the relationships between the four key proteins.\n\nKey strengths of this visualization:\n1. Clear protein representation with consistent color-coding and labeling\n2. Distinct arrows showing activation (green) and inhibition (red) relationships\n3. Proper indication of molecular functions for each protein\n4. Appropriate cellular compartmentalization\n5. Comprehensive legend that explains both the proteins and interaction types\n6. Professional appearance suitable for journal publication\n\nThe diagram accurately represents all elements from the GO-CAM model while presenting them in a visually appealing and scientifically informative manner that would be appropriate for a high-impact journal figure.","necessary_changes":null,"optional_changes":"For future iterations, consider adding references to the specific PMIDs mentioned in the original GO-CAM model to further enhance the scientific documentation aspect."}