Figure: CMP catabolic process (Mouse)¶
This diagram illustrates the CMP (cytidine monophosphate) catabolic process in mouse. The pathway consists of six sequential enzymatic steps:
Step 1: Nt5c3 (5'-nucleotidase) removes the phosphate group from CMP to produce cytidine. Step 2: Cda (cytidine deaminase) deaminates cytidine to form uridine. Step 3: Upp1/Upp2 (uridine phosphorylase) cleaves the ribose from uridine to produce uracil. Step 4: Dpyd (dihydropyrimidine dehydrogenase) reduces uracil to dihydrouracil. Step 5: Dpys (dihydropyrimidinase) hydrolyzes the dihydrouracil ring to form N-carbamoyl-β-alanine. Step 6: Upb1 (beta-ureidopropionase) cleaves the carbamoyl group to produce the final product β-alanine.
All reactions occur in the cytosol compartment. Enzymes are shown as red rounded rectangles, metabolites as blue circles, and reaction zones as light blue backgrounds. The pathway represents a complete route for breaking down CMP to salvageable components.
Feedback from AI on figure:
{"feedback":"The diagram clearly presents the CMP catabolic process pathway in mouse with excellent scientific accuracy and artistic presentation. The sequential enzymatic steps are well-organized and easy to follow, with each reaction clearly labeled. The addition of step numbers and subtle background zones helps differentiate between different stages of the pathway.\n\nThe visual hierarchy is appropriate, with enzymes prominently displayed in red rounded rectangles and metabolites in blue circles. The brief functional descriptions for each enzyme add valuable context without cluttering the diagram. The improved font sizing ensures all text is clearly legible, and the proper chemical notation (subscripts in NH₃ and CO₂) adds professional polish.\n\nThe layout mimics the style of figures found in high-impact journals like Cell and Nature, with a clean, minimalist approach that focuses on the biological information. The legend effectively explains all the elements in the diagram.","necessary_changes":null,"optional_changes":null}