Figure: Sphingomyelin phosphodiesterase activity involved in viral entry (Human-Sars-Cov-2)¶
The diagram illustrates the role of sphingomyelin phosphodiesterase activity in SARS-CoV-2 viral entry into human cells. SMPD1 (sphingomyelin phosphodiesterase 1) is shown in both lysosomal and extracellular compartments, where it catalyzes sphingomyelin phosphodiesterase activity (GO:0004767) contributing to ceramide biosynthesis (GO:0046513). In the lysosome, SMPD1 positively regulates NPC2 (Niemann-Pick C2 protein), which mediates cholesterol transfer activity (GO:0120020) and promotes cholesterol efflux (GO:0033344). SMPD1 also positively regulates ACE2 (Angiotensin-converting enzyme 2) at the plasma membrane, which functions as a virus receptor (GO:0001618) for SARS-CoV-2, facilitating viral entry into the host cell (GO:0046718).
Feedback from AI on figure:
{"feedback":"This detailed pathway diagram effectively illustrates the role of sphingomyelin phosphodiesterase activity in SARS-CoV-2 viral entry. The drawing clearly depicts the spatial organization of key proteins (SMPD1, NPC2, and ACE2) across different cellular compartments (extracellular space, plasma membrane, and lysosome). The regulatory relationships between these components are well-represented with appropriate arrows and labels, and the molecular functions (sphingomyelin phosphodiesterase activity, cholesterol transfer activity, and virus receptor activity) are clearly indicated. The diagram uses a consistent color scheme that helps distinguish different proteins and processes, with a helpful legend for reference. The addition of GO term identifiers provides valuable annotation for scientific accuracy.","necessary_changes":null,"optional_changes":null}