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Figure: circadian rhythm and hematopoiesis via ezh2, per1b, cry1a etc. (D. rerio)

id: gomodel:5fb9cc0600000156

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This diagram illustrates the molecular pathway connecting circadian rhythm and hematopoiesis in zebrafish (D. rerio). The central elements are:

  1. Circadian rhythm regulators: The CLOCK-BMAL complex (CLOCK/BMAL1B) acts as a master regulator of the circadian cycle. This complex is positively regulated by EZH2 and RORAA, while negatively regulated by CRY1A and NR1D1.

  2. Transcriptional regulation: The diagram shows how circadian factors function as transcriptional coactivators (EZH2) or corepressors (CRY1A), controlling the expression of target genes.

  3. Hematopoiesis connection: The pathway demonstrates how circadian rhythm components influence blood cell formation through EZH2's positive regulation of hematopoiesis and the CLOCK-BMAL complex regulation of MYB and LCK.

  4. Feedback loops: The diagram captures the core circadian feedback loops, where the CLOCK-BMAL complex promotes expression of PER1B, which feeds back into the system.

The arrows indicate regulatory relationships: green arrows show positive regulation (activation), red arrows show negative regulation (repression), and black arrows indicate general associations. Dashed lines represent indirect regulatory effects between biological processes.

Feedback from AI on figure:

{"feedback":"This molecular pathway diagram effectively captures the complex interactions between circadian rhythm regulation and hematopoiesis in zebrafish. The visual representation clearly distinguishes between different types of proteins and their regulatory functions using appropriate colors and shapes. The directional arrows with plus/minus symbols make the regulatory relationships immediately apparent, and the addition of molecular function labels provides valuable context for each component's role.","necessary_changes":null,"optional_changes":"Consider adding timestamps or indication of temporal sequence for the circadian rhythm components if that information is available in the original GO-CAM. Additionally, a small note could be added to indicate which components are from the original GO-CAM and which details were filled in for clarity."}