Figure: Regulation of macrophage differntiation via irf2bp2b, cebpa, spi1b (D. rerio)¶
This diagram illustrates the regulation of macrophage differentiation in Danio rerio (zebrafish) involving three key transcription factors: cebpa, irf2bp2b, and spi1b.
cebpa (blue box) functions as a transcriptional activator that can bind to DNA and activate its own expression. It promotes the expression of spi1b (green box).
irf2bp2b (red box) functions as a transcriptional repressor. It inhibits the negative regulation of macrophage differentiation process and also represses spi1b expression.
spi1b is required for macrophage differentiation (tan box at bottom), which is the end biological process in this pathway.
The diagram shows how these transcription factors work together to regulate macrophage differentiation, with arrows indicating activation (green) or repression (red) relationships between components.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the regulatory network controlling macrophage differentiation in zebrafish. The visual hierarchy clearly shows the relationships between the three key transcription factors (cebpa, irf2bp2b, and spi1b) and their effects on macrophage differentiation. The cellular compartmentalization (nucleus vs. cytoplasm) helps contextualize where these molecular interactions take place. The color coding is intuitive, with activators in blue, repressors in red, and the target gene in green, making the regulatory logic easy to follow at a glance. Line weights, text sizes, and arrow styles have been optimized for clarity and readability, making this suitable for publication in a scientific journal.","necessary_changes":null,"optional_changes":null}