Figure: Triacyl lipopetide activation of TLR1-TLR2 complex (Human)¶
This figure illustrates the triacyl lipopeptide activation pathway of the TLR1-TLR2 complex in human cells. In the extracellular space, LBP (P18428) and CD14 (P08571) proteins function as molecular carriers that bind to triacyl lipopeptide (CHEBI:60192) and transport it to the TLR1-TLR2 heterodimer complex (Q15399, O60603) located in plasma membrane rafts. Upon binding the lipopeptide, the TLR1-TLR2 complex undergoes activation and triggers transmembrane signaling, which recruits the adaptor protein TIRAP (P58753) to the cytoplasmic side of the plasma membrane. TIRAP functions as a protein-macromolecule adaptor in the TLR1:TLR2 signaling pathway (GO:0038123), facilitating downstream signal transduction events.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the triacyl lipopeptide activation of the TLR1-TLR2 complex pathway with clarity and precision. The visual representation follows the standard conventions of scientific journal figures, with appropriate use of distinct shapes, colors, and labels to identify key molecular components. The spatial organization clearly shows the progression from extracellular binding events to transmembrane signaling and cytoplasmic adaptation. The inclusion of UniProt identifiers and GO terms enhances the scientific accuracy of the illustration.","necessary_changes":null,"optional_changes":"The diagram could potentially benefit from indicating potential downstream signaling events that might follow TIRAP activation, even if just suggested with a dotted arrow pointing to unspecified further components. Additionally, including a brief note about the physiological significance of this pathway (e.g., immune response triggering) might provide helpful context for readers."}