Figure: BMP2-SMAD signaling mouse¶
This figure illustrates the BMP2-SMAD signaling pathway in mouse cells. BMP2 ligand binds to the receptor complex comprising BMPR2 and BMPR1A at the plasma membrane. This binding activates phosphorylation cascades, leading to phosphorylation of both receptors. Activated BMPR1A phosphorylates cytoplasmic SMAD1, which then translocates to the nucleus where it functions as a transcription factor to regulate target gene expression. The diagram also shows clathrin-dependent endocytosis involving EPS15L1 protein, which contributes to receptor internalization and signal regulation.
Feedback from AI on figure:
{"feedback":"The final diagram effectively illustrates the BMP2-SMAD signaling pathway in mouse with excellent clarity and professional style suitable for publication in journals like Cell or Nature. The key components (BMP2 ligand, BMPR2/BMPR1A receptors, SMAD1, and clathrin-dependent endocytosis) are well-represented with appropriate visual hierarchy. Text elements are now clearly legible with improved font sizes and weights. The directionality of signaling is clearly indicated with properly sized arrows, including the addition of an arrowhead to the clathrin-endocytosis pathway. The cellular compartments are distinctly delineated, and the molecular functions are clearly labeled. The color scheme helps differentiate between components while maintaining a cohesive scientific illustration style.","necessary_changes":null,"optional_changes":null}