Figure: BMP2-MAPK signaling mouse¶
This figure depicts the BMP2-MAPK signaling pathway in mouse cells, illustrating the molecular cascade that regulates osteoblast differentiation and bone development. BMP2 (bone morphogenetic protein 2) in the extracellular space binds to and activates a receptor complex consisting of BMPR1A, BMPR1B, and BMPR2 at the cell membrane. Signal transduction proceeds through a series of phosphorylation events involving MAP3K7 (TAK1), MAP2K6, and the MAPKs (MAPK11/p38β and MAPK14/p38α) in the cytosol. These kinases ultimately activate the transcription factor RUNX2 in the nucleus, which drives the expression of genes essential for bone formation including SP7 (Osterix), IBSP (bone sialoprotein), ALPL (alkaline phosphatase), and BGLAP (osteocalcin). The pathway represents a key mechanism by which BMP2 stimulates osteoblast differentiation and bone matrix production.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the BMP2-MAPK signaling pathway in mouse cells with clear visual organization that would be appropriate for publication in journals like Cell or Nature. The pathway components are arranged in a logical flow from the extracellular BMP2 ligand through membrane-bound receptors, cytosolic kinase cascade, and ultimately to nuclear transcription factors and target genes.","necessary_changes":null,"optional_changes":null}