Skip to content

Figure: SPModule-PGLYRP1/HSP701A

id: gomodel:5fce9b7300001590

img

The diagram represents the SPModule-PGLYRP1/HSP701A pathway in humans (Homo sapiens), illustrating interactions between key proteins:

  1. HSPA1A (UniProtKB:P0DMV8, orange circle): Heat shock protein displaying receptor ligand activity in the extracellular space
  2. PGLYRP1 (UniProtKB:O75594, blue rectangle): Peptidoglycan recognition protein with Hsp70 protein binding activity
  3. HSPBP1 (UniProtKB:Q9NZL4, green rectangle): Heat shock protein binding protein with molecular sequestering activity
  4. TNFRSF1A (UniProtKB:P19438-1, yellow rectangle): TNF receptor located on the cell surface

The pathway shows: - PGLYRP1 positively regulates (promotes) HSPA1A's activity (RO:0002629) - HSPBP1 negatively regulates (inhibits) PGLYRP1 (RO:0002630) - HSPA1A activates TNFRSF1A on the cell surface (RO:0002629)

All interactions occur in the extracellular space (GO:0005615), except for TNFRSF1A which is located on the cell surface (GO:0009986).

Feedback from AI on figure:

{"feedback":"This diagram effectively illustrates the SPModule-PGLYRP1/HSP701A pathway in a clear and visually appealing format suitable for publication in a scientific journal. The improved font sizes enhance readability across all elements, and the expanded labels on the interaction arrows provide valuable information about the relationship types. The color scheme clearly differentiates between the various proteins and their functions, and the compartmentalization between extracellular space and cell surface is well-defined. The legend is comprehensive and properly sized, making the entire figure accessible and informative.","necessary_changes":null,"optional_changes":null}