Figure: SPModule-PGRP1-S100A4¶
This pathway diagram illustrates the signaling cascade initiated by PGLYRP1 (Peptidoglycan recognition protein 1) in the extracellular space, which positively regulates S100A4 (S100 calcium binding protein A4). S100A4 acts as a chemoattractant that subsequently positively regulates two cell surface chemokine receptors: CXCR3 (C-X-C motif chemokine receptor 3) and CCR5 (C-C motif chemokine receptor 5).
The diagram depicts three main molecular activities from the GO-CAM model: 1. PGLYRP1 exhibits molecular adaptor activity in the extracellular space 2. S100A4 shows chemoattractant activity in the extracellular space 3. CXCR3 and CCR5 function as C-C chemokine receptors on the cell surface
The arrows represent positive regulatory relationships (RO:0002629) between these components, showing the directional flow of the signaling pathway.
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively illustrates the PGLYRP1-S100A4 signaling pathway, clearly showing the relationships between the key proteins and their molecular functions. The spatial organization distinguishes between extracellular space and cell surface components, with appropriate protein representations and clearly labeled regulatory relationships. The color coding helps differentiate between protein types, and the expanded legend provides helpful context about each component.","necessary_changes":null,"optional_changes":null}