Figure: Strap in alternative splicing-mouse¶
This figure depicts the molecular pathway of Strap (serine-threonine kinase receptor-associated protein) in alternative splicing in mouse. Within the nucleus, Strap (MGI:1329037) performs multiple molecular functions: U2 snRNP binding (GO:1990447) and mRNA binding (GO:0003729). These functions contribute to two biological processes: protein-RNA complex assembly (GO:0022618) and alternative mRNA splicing via spliceosome (GO:0000380). Strap negatively regulates (inhibits) the transcription factors Sp1 (MGI:98372) and Klf9 (MGI:1333856), which otherwise positively regulate expression of Cyp26a1 (MGI:1096359). Cyp26a1 functions as a retinoic acid 4-hydroxylase that mediates retinoic acid catabolic process (GO:0034653).
Feedback from AI on figure:
{"feedback":"The SVG drawing effectively illustrates the GO-CAM pathway showing Strap's role in alternative splicing. The diagram has a clear layout with the nucleus appropriately depicted, and molecular interactions are represented with distinct shapes and colors that are well-explained in the legend. The text is properly sized for readability, and the connections between components use appropriate line styles and directional indicators to show positive and negative regulation. The larger font sizes for gene names and process labels improve clarity compared to earlier versions, making the diagram suitable for publication in scientific journals.","necessary_changes":null,"optional_changes":null}