Figure: Inosine catabolic process (Mouse)¶
Gene products in this diagram: - Pnp (MGI:97365): Purine-nucleoside phosphorylase, converts inosine to hypoxanthine - Xdh (MGI:98973): Xanthine dehydrogenase/oxidase, catalyzes hypoxanthine → xanthine → urate - Uox (MGI:98907): Urate oxidase, converts urate to hydroxyisourate (HIU) - Urah (MGI:1916142): Hydroxyisourate hydrolase, converts HIU to OHCU - Urad (MGI:3647519): OHCU decarboxylase, catalyzes final step to allantoin
The pathway shows the complete inosine catabolic process in mouse cells, spanning two cellular compartments: cytosol (upper region) and peroxisome (lower region). The initial steps (inosine → hypoxanthine → xanthine → urate) occur in the cytosol, followed by transport of urate to the peroxisome, where the final degradation steps to allantoin take place.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the inosine catabolic pathway in mouse cells with scientific accuracy and visual clarity. The pathway progression is logically arranged from inosine to allantoin, with appropriate compartmentalization between cytosol and peroxisome. The gene products (Pnp, Xdh, Uox, Urah, and Urad) are clearly labeled with their molecular functions, matching the GO-CAM data provided. The metabolic intermediates are clearly depicted, and the directional flow is well-represented with consistent arrows. The added transport indication between compartments enhances understanding of the biological process.","necessary_changes":null,"optional_changes":null}