Figure: NLRP3 inflammasome in pyroptosis via nlrp3, caspa, caspb etc. (D. rerio)¶
This figure illustrates the NLRP3 inflammasome pathway leading to pyroptosis in Danio rerio (zebrafish). The pathway begins with NLRP3 and ASC (pycard) forming the NLRP3 inflammasome complex. This complex activates caspase proteins (caspa and caspb), which undergo self-proteolysis for activation. The activated caspases then cleave and activate gasdermin proteins (gsdmea and gsdmeb), which form pores in the cell membrane, leading to pyroptotic cell death characterized by cell swelling, membrane rupture, and release of inflammatory contents including IL-1β (the IL-1β component is inferred and not explicitly stated in the GO-CAM). This pathway represents a key inflammatory cell death mechanism in zebrafish.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the NLRP3 inflammasome pathway in zebrafish, showing the sequence from complex formation to pyroptotic cell death. The use of different colored elements helps distinguish between protein types, and the arrows clearly indicate activation pathways and mechanisms. The addition of a comprehensive legend enhances understanding of the symbols and their meanings.","necessary_changes":null,"optional_changes":"For future improvements, consider standardizing biological symbols to align with conventional pathway notation systems used in journals like Cell or Nature."}