Figure: Guanine catabolic process (Mouse)¶
This diagram illustrates the guanine catabolic pathway in mice (Mus musculus), showing the enzymatic conversion of guanine to allantoin. The pathway begins in the cytosol with guanine deaminase (Gda) converting guanine to xanthine. Xanthine is then oxidized by xanthine dehydrogenase/oxidase (Xdh) to form urate. The remaining steps occur in the peroxisome: urate is converted to 5-hydroxyisourate (5-HIU) by urate oxidase (Uox), followed by conversion to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) by hydroxyisourate hydrolase (Urah), and finally to allantoin by OHCU decarboxylase (Urad). This pathway represents purine catabolism in mice, with allantoin as the final product.
Feedback from AI on figure:
{"feedback":"The final drawing effectively illustrates the guanine catabolic pathway in mice with clear compartmentalization between the cytosol and peroxisome. The pathway flow is logical and easy to follow, with well-labeled enzymes and metabolites. The inclusion of chemical formulas for each metabolite adds scientific detail, while the MGI gene IDs provide reference information for the enzymes. The color coding distinguishes between different components, and the legend clearly explains all elements used in the diagram. The text is appropriately sized for readability, and the overall layout resembles a professional figure suitable for publication in scientific journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}