Figure: Deoxyadenosine catabolic process (Mouse)¶
This figure illustrates the deoxyadenosine catabolic process in mouse (GO:0006157). The pathway begins in the cytosol (light blue) with adenosine deaminase (Ada) catalyzing the deamination of 2'-deoxyadenosine to 2'-deoxyinosine. Purine nucleoside phosphorylase (Pnp) then converts 2'-deoxyinosine to hypoxanthine. Xanthine dehydrogenase/oxidase (Xdh) performs sequential activities: first converting hypoxanthine to xanthine (via hypoxanthine dehydrogenase/oxidase activity), then xanthine to urate (via xanthine dehydrogenase/oxidase activity). Urate is transported to the peroxisome (light red), where urate oxidase (Uox) converts it to hydroxyisourate. Hydroxyisourate hydrolase (Urah) then processes hydroxyisourate to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU), which is finally converted to allantoin by 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (Urad).
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively illustrates the deoxyadenosine catabolic process in mouse, presented in a publication-quality format suitable for journals like Cell or Nature. The diagram clearly delineates the two cellular compartments (cytosol and peroxisome) using distinct color coding. Each enzyme is represented with its gene symbol and GO molecular function ID, while metabolites are clearly labeled at each step of the pathway. The directional flow is logical and easy to follow, with appropriate arrows indicating the progression from 2'-deoxyadenosine to allantoin. The transport of urate from cytosol to peroxisome is clearly marked with a dashed line, and a comprehensive legend helps readers interpret all visual elements.","necessary_changes":null,"optional_changes":null}