Figure: Deoxyguanosine catabolic process (Mouse)¶
This figure depicts the deoxyguanosine catabolic process in mouse (GO:0006161). The pathway spans two cellular compartments: cytosol and peroxisome. In the cytosol, deoxyguanosine is first processed by Pnp (purine nucleoside phosphorylase, MGI:97365) to produce guanine, which is then converted to xanthine by Gda (guanine deaminase, MGI:95678). Xanthine is subsequently oxidized to uric acid by Xdh (xanthine dehydrogenase, MGI:98973). Uric acid is transported to the peroxisome where it undergoes further degradation: first converted to 5-HIU (5-hydroxyisourate) by Uox (urate oxidase, MGI:98907), then to OHCU (2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline) by Urah (hydroxyisourate hydrolase, MGI:1916142), and finally to allantoin by Urad (OHCU decarboxylase, MGI:3647519). Transport of uric acid from cytosol to peroxisome (shown as dashed line) is implied in the pathway but not explicitly represented in the original GO-CAM model.
Feedback from AI on figure:
{"feedback":"The diagram clearly illustrates the deoxyguanosine catabolic pathway in mouse, accurately representing the processes occurring in both cytosolic and peroxisomal compartments. The pathway flow is logically presented with clear directional arrows showing the progression from deoxyguanosine to allantoin. Each enzyme and its corresponding molecular function is properly labeled, making it easy to track the chemical transformations.","necessary_changes":null,"optional_changes":null}