Figure: Deoxyinosine catabolic process (Mouse)

id: gomodel:60418ffa00001643

Legend:

Enzymes: - Pnp: Purine-nucleoside phosphorylase (MGI:97365) - Xdh: Xanthine dehydrogenase/oxidase (MGI:98973) - Uox: Urate oxidase (MGI:98907) - Urah: Hydroxyisourate hydrolase (MGI:1916142) - Urad: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (MGI:3647519)

Substrates/Products: - Deoxyinosine → Hypoxanthine (via Pnp) - Hypoxanthine → Urate (via Xdh) - Urate → 5-Hydroxyisourate (via Uox) - 5-Hydroxyisourate → 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (via Urah) - 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline → Allantoin (via Urad)

Cellular Compartments: - Cytosol: Location of initial reactions (Pnp, Xdh) - Peroxisome: Location of final catabolic reactions (Uox, Urah, Urad)

Color Coding: - Yellow rectangles: Metabolites - Red circles: Cytosolic enzymes - Blue circles: Peroxisomal enzymes

Feedback from AI on figure:

{"feedback":"This pathway diagram effectively illustrates the deoxyinosine catabolic process in mice, presenting a clear visual flow from the initial substrate to the final product. The drawing successfully conveys the sequence of enzymatic reactions, with well-labeled enzymes and metabolites. The spatial organization clearly distinguishes between cytosolic and peroxisomal processes, which is crucial for understanding the compartmentalization of this metabolic pathway.\n\nThe use of color coding helps differentiate between enzymes and substrates, making the diagram easy to follow. The addition of reaction type labels (phosphorolysis, oxidation, hydrolysis, decarboxylation) next to the arrows provides valuable information about the chemical transformations occurring at each step.\n\nThe diagram maintains the scientific accuracy required for a professional journal figure while incorporating enough artistic elements to make it visually appealing and informative.","necessary_changes":null,"optional_changes":null}