Figure: canonical Wnt signaling pathway via wg-fz2 (D.mel)¶
The diagram illustrates the canonical Wnt signaling pathway in Drosophila melanogaster, focusing on its negative regulation.
Key components: - Wingless (wg): The Wnt ligand secreted into the extracellular space - Frizzled2 (fz2): Primary Wnt receptor in the plasma membrane - Arrow (arr): Co-receptor that forms a complex with Frizzled - Dishevelled (dsh): Adaptor protein that transduces the signal from receptors - Destruction complex: Contains Axin (Axn), APC2, Shaggy (sgg), and CKIα - Roc1a: E3 ubiquitin ligase component - Armadillo (arm): Drosophila β-catenin homolog and key effector
Signaling events: 1. In the absence of Wnt signaling, the destruction complex phosphorylates Armadillo, marking it for ubiquitination by Roc1a and subsequent degradation. 2. When Wingless binds to Frizzled2 and Arrow, Dishevelled is activated and inhibits the destruction complex. 3. This inhibition allows Armadillo to accumulate, translocate to the nucleus, and activate target gene expression.
The pathway is shown with cellular compartmentalization (extracellular space, plasma membrane, cytosol, and nucleus) to represent the spatial regulation of signaling. Green arrows indicate activating interactions, while red arrows represent inhibitory interactions.
Feedback from AI on figure:
{"feedback":"This diagram effectively represents the canonical Wnt signaling pathway in Drosophila melanogaster with a clear focus on negative regulation. The cellular compartmentalization is well-defined with distinct colors and boundaries, making it immediately clear where each protein is localized. The use of different shapes and colors for various protein types (ligands, receptors, kinases, etc.) enhances clarity and allows for quick visual identification.\n\nThe interaction arrows are clearly color-coded (green for activation, red for inhibition) with appropriate directionality, effectively showing the flow of signaling. Key elements like the destruction complex are highlighted with a dashed outline, creating visual organization. The enlarged text improves readability, and the comprehensive legend provides clear identification of all components.\n\nThe figure maintains the scientific accuracy required for a journal publication while using artistic elements to enhance understanding of the pathway dynamics.","necessary_changes":null,"optional_changes":null}