Figure: Atf2 mouse¶
This diagram illustrates the molecular interactions and cellular processes involving ATF2 (Activating Transcription Factor 2) in mouse cells. The central red circle represents ATF2, which interacts with various proteins including JDP2, JUN, and FOS (blue circles) through protein-protein interactions. ATF2 is regulated by signaling kinases p38 and JNK (orange circles) through phosphorylation events.
The diagram shows ATF2's involvement in multiple biological processes (gray boxes) including gene expression, apoptosis, cell differentiation, stress response, and immune response. ATF2 functions in various cell types (tan boxes) including melanocytes, neurons, macrophages, chondrocytes, keratinocytes, and adipocytes.
The nuclear compartment (light blue inner oval) contains most of the transcriptional regulatory activity, while the cytoplasm (light blue outer region) contains signaling molecules. Solid lines represent direct protein interactions, arrows indicate signal transduction or modification events, and dashed lines show associations with biological processes.
The diagram demonstrates ATF2's central role as a transcriptional regulator that integrates various cellular signals and contributes to multiple biological processes across different cell types.
Feedback from AI on figure:
{"feedback":"This diagram effectively captures the complex role of ATF2 in various cellular processes and molecular interactions. The layout is clear and well-organized, with the cellular compartments distinctly delineated and ATF2 prominently positioned in the nucleus. The improved visual hierarchy with larger font sizes and increased contrast between text and background colors enhances readability significantly.\n\nThe diagram successfully illustrates ATF2's interactions with various proteins (JDP2, JUN, FOS, etc.), the regulatory influence of signaling molecules (p38, JNK), and connections to different biological processes (gene expression, apoptosis, cell differentiation, etc.). The cell type-specific roles are also well represented.\n\nThe comprehensive legend provides clear information about the color-coding and types of connections, making the diagram accessible even to readers less familiar with molecular pathway representations.","necessary_changes":null,"optional_changes":null}