Figure: activin receptor signaling pathway via Actbeta-babo/put (D.mel)¶
This diagram depicts the activin receptor signaling pathway in Drosophila melanogaster based on the GO-CAM model (gomodel:60ad85f700000259).
The pathway begins in the extracellular space with Actbeta (FBgn0024913), which exhibits cytokine activity. Actbeta activates the receptors Baboon (Babo, FBgn0011300) and Punt (Put, FBgn0003169) located on the plasma membrane. Both receptors have activin receptor activity.
Signal transduction continues into the cytoplasm where Smox (FBgn0025800) is activated through co-SMAD binding. Smox and Medea (Med, FBgn0288966) translocate to the nucleus where they function as transcription factors - Smox with DNA-binding transcription factor activity and Med with DNA-binding transcription activator activity.
The illustration shows the complete signaling cascade from extracellular ligand binding to nuclear transcription factor activation, representing the key components of the activin receptor signaling pathway.
Feedback from AI on figure:
{"feedback":"This illustration effectively captures the activin receptor signaling pathway in Drosophila melanogaster as described in the GO-CAM model. The diagram presents a clear visual representation of signal transduction from the extracellular space through the plasma membrane to the nucleus.\n\nThe drawing uses appropriate colors and shapes to distinguish between different molecular components, with a well-organized cellular cross-section that clearly delineates the different cellular compartments. The directional flow of signaling is indicated by well-placed arrows, and the molecular functions are properly annotated.\n\nAll text elements are sized appropriately for readability, and the legend provides clear identification of the pathway components. The diagram maintains scientific accuracy while presenting the information in a visually appealing format suitable for publication in journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}