Figure: Notch signaling pathway via N-Dl (D.mel)¶
This illustration depicts the Notch signaling pathway in Drosophila melanogaster, as described in the GO-CAM model (gomodel:60ad85f700000309). The pathway begins with Delta (FBgn0000463) in the sending cell membrane binding to Notch receptor (FBgn0004647) on the receiving cell (step 1). This interaction triggers a series of proteolytic cleavages: first by Kuzbanian/kuz (FBgn0259984) metalloendopeptidase at the cell surface (step 2), followed by Presenilin/Psn (FBgn0284421) endopeptidase (step 3). These cleavages release the Notch intracellular domain (NICD) (step 4), which translocates to the nucleus where it functions as a transcription coactivator (step 5). Numbered circles indicate the sequence of events in this signaling cascade. All elements depicted are present in the original GO-CAM model, with no implicit additions.
Feedback from AI on figure:
{"feedback":"This illustration effectively captures the Notch signaling pathway in Drosophila melanogaster as described in the GO-CAM model. The drawing presents a clear, journal-quality figure with appropriate scientific styling suitable for publications like Cell or Nature.\n\nStrengths of the illustration include:\n1. Well-organized spatial layout showing signal transduction between sending and receiving cells\n2. Clear labeling of all key gene products (Delta, Notch, Kuzbanian, Presenilin) with their FlyBase identifiers\n3. Logical flow of the signaling process with numbered steps making the sequence easy to follow\n4. Proper representation of subcellular localization (membrane proteins, nuclear translocation)\n5. Effective use of color coding that enhances readability without being distracting\n6. Comprehensive legend that explains all components and processes\n\nThe drawing faithfully represents all elements from the GO-CAM model without adding implicit details that weren't in the source. The proteolytic cascade is correctly depicted, showing how the Notch receptor is cleaved first by Kuzbanian metalloendopeptidase and then by Presenilin endopeptidase, leading to the release and nuclear translocation of the NICD, where it acts as a transcription coactivator.\n\nThe illustration would be an excellent accompaniment to a scientific publication on Notch signaling in Drosophila.","necessary_changes":null,"optional_changes":null}