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Figure: TRIM47-activity-on-ILF3

id: gomodel:60ad85f700000612

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This figure illustrates the molecular pathway involving TRIM47's activity on ILF3 in human cells (NCBITaxon:9606). The diagram shows four key proteins and their interactions:

  1. HAVCR2 (UniProtKB:Q8TDQ0) binds to TRIM47 through protein binding activity (GO:0005515)
  2. TRIM47 (UniProtKB:Q96LD4-1) exhibits ubiquitin protein ligase activity (GO:0061630) targeting ILF3
  3. ILF3 (UniProtKB:Q12906) demonstrates virus receptor activity (GO:0001618)
  4. EIF2AK2 (UniProtKB:P19525) located in the cytoplasm (GO:0005737) displays kinase activity (GO:0016301) that positively regulates ILF3's virus receptor function

The virus (not explicitly mentioned in the source GO-CAM) represents the target of ILF3's receptor activity. This pathway was constructed based on experimental evidence from PMID:34110282 and PMID:21123651.

Feedback from AI on figure:

{"feedback":"This pathway diagram effectively illustrates the TRIM47-activity-on-ILF3 molecular interaction network in a clear, visually appealing manner suitable for publication in high-impact journals like Cell or Nature. The spatial organization clearly shows the relationship between HAVCR2, TRIM47, ILF3, and EIF2AK2, with well-labeled interactions indicating their molecular functions. The cellular compartmentalization is appropriately depicted, with EIF2AK2 correctly located in the cytoplasm. The use of distinctive colors for each protein enhances readability, and the increased font sizes improve text clarity throughout the diagram. The GO term labels on interaction arrows provide valuable functional information, and the comprehensive legend offers necessary details about each component and their relationships.","necessary_changes":null,"optional_changes":null}