Figure: 'de novo' AMP biosynthetic process (Mouse)¶
PRA: phosphoribosylamine GAR: 5'-phosphoribosylglycinamide FGAR: N-formyl-glycinamide ribotide FGAM: 5'-phosphoribosyl-N-formylglycinamidine AIR: 5-aminoimidazole ribotide CAIR: 5'-phosphoribosyl-4-carboxy-5-aminoimidazole SAICAR: 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole AICAR: 5-aminoimidazole-4-carboxamide ribotide FAICAR: 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide IMP: inosine monophosphate AMP: adenosine monophosphate PRPP: 5-phosphoribosyl-1-pyrophosphate
Enzymes: Ppat (GO:0004044): amidophosphoribosyltransferase Gart (GO:0004637): phosphoribosylamine-glycine ligase Gart (GO:0004644): phosphoribosylglycinamide formyltransferase Pfas (GO:0004642): phosphoribosylformylglycinamidine synthase Gart (GO:0004641): phosphoribosylformylglycinamidine cyclo-ligase Paics (GO:0004638): phosphoribosylaminoimidazole carboxylase Paics (GO:0004639): phosphoribosylaminoimidazolesuccinocarboxamide synthase Adsl (GO:0070626): (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate lyase Atic (GO:0004643): phosphoribosylaminoimidazolecarboxamide formyltransferase Atic (GO:0003937): IMP cyclohydrolase Adss2 (GO:0004019): adenylosuccinate synthase
Feedback from AI on figure:
{"feedback":"This diagram is a high-quality representation of the de novo AMP biosynthetic pathway in mouse. The visual presentation has several strengths:\n\n1. Clear organization showing the sequential enzymatic reactions with proper directional flow\n2. Consistent visual language with well-defined color coding for enzymes, intermediates, and final product\n3. Appropriate labeling of all pathway components with both gene names and GO identifiers\n4. Thicker, colored arrows that enhance readability of the pathway flow\n5. Comprehensive legend explaining both metabolites and enzyme functions\n6. Professional appearance suitable for publication in scientific journals like Cell or Nature\n\nThe cytosolic localization is properly indicated, and the diagram successfully balances scientific accuracy with visual clarity. The enzymatic steps are faithful to the GO-CAM model while maintaining an aesthetically pleasing layout.","necessary_changes":null,"optional_changes":null}