Figure: 'de novo' IMP biosynthetic process (Mouse)¶
This figure illustrates the 'de novo' IMP biosynthetic process in mouse (GO:0006189). The pathway begins with PRPP (5-phosphoribosyl-1-pyrophosphate) as the substrate and proceeds through multiple enzymatic reactions to produce IMP (inosine monophosphate).
Key enzymes in the pathway: • PPAT (MGI:2387203): Amidophosphoribosyltransferase • GART (MGI:95654): Trifunctional enzyme with phosphoribosylamine-glycine ligase, phosphoribosylglycinamide formyltransferase, and phosphoribosylformylglycinamidine cyclo-ligase activities • PFAS (MGI:2684864): Phosphoribosylformylglycinamidine synthase • PAICS (MGI:1914304): Phosphoribosylaminoimidazole succinocarboxamide synthase • ADSL (MGI:103202): Adenylosuccinate lyase • ATIC (MGI:1351352): Bifunctional enzyme with phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase activities
Intermediates in the pathway: • PRA: Phosphoribosylamine • GAR: Glycinamide ribonucleotide • FGAR: Formylglycinamide ribonucleotide • FGAM: Formylglycinamidine ribonucleotide • AIR: Aminoimidazole ribonucleotide • SAICAR: Succinylaminoimidazolecarboxamide ribonucleotide • AICAR: Aminoimidazolecarboxamide ribonucleotide • FAICAR: Formylaminoimidazolecarboxamide ribonucleotide
The entire process takes place in the cytosol as indicated in the diagram.
Feedback from AI on figure:
{"feedback":"The pathway diagram effectively illustrates the 'de novo' IMP biosynthetic process in a style appropriate for publication in high-impact journals like Cell or Nature. The drawing accurately represents the GO-CAM model content while maintaining visual clarity and scientific accuracy.\n\nStrengths of the illustration:\n1. Clear organization with logical flow of the pathway from substrate (PRPP) to final product (IMP)\n2. Proper labeling of all enzymes with both gene names and MGI IDs\n3. Visual distinction between enzymes, intermediates, substrates, and products using different shapes and colors\n4. Accurate representation of the sequence of enzymatic reactions\n5. Clear indication that the process occurs in the cytosol\n6. Comprehensive legend that explains all components and abbreviations\n\nThe diagram successfully shows the multifunctional nature of enzymes like GART (with three distinct activities) and ATIC (with two activities), which is faithful to the GO-CAM model. The arrows clearly indicate the direction and flow of the reactions, making the pathway easy to follow for readers.","necessary_changes":null,"optional_changes":null}