Figure: 'de novo' GMP biosynthetic process (Mouse)¶
PRPP: Phosphoribosyl pyrophosphate 5-PRA: 5-Phosphoribosylamine GAR: Glycinamide ribonucleotide FGAR: Formylglycinamide ribonucleotide FGAM: Formylglycinamidine ribonucleotide AIR: Aminoimidazole ribonucleotide CAIR: Carboxyaminoimidazole ribonucleotide SAICAR: Succinylaminoimidazolecarboxamide ribonucleotide AICAR: Aminoimidazolecarboxamide ribonucleotide FAICAR: Formylaminoimidazolecarboxamide ribonucleotide IMP: Inosine monophosphate XMP: Xanthosine monophosphate GMP: Guanosine monophosphate
Enzymes: Ppat (MGI:2387203): Amidophosphoribosyltransferase Gart (MGI:95654): Multifunctional enzyme with phosphoribosylamine-glycine ligase, phosphoribosylglycinamide formyltransferase, and phosphoribosylformylglycinamidine cyclo-ligase activities Pfas (MGI:2684864): Phosphoribosylformylglycinamidine synthase Paics (MGI:1914304): Bifunctional enzyme with phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase activities Adsl (MGI:103202): Adenylosuccinate lyase Atic (MGI:1351352): Bifunctional enzyme with phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase activities Impdh1/2 (MGI:96567/109367): IMP dehydrogenase Gmps (MGI:2448526): GMP synthase
Feedback from AI on figure:
{"feedback":"This diagram clearly represents the 'de novo' GMP biosynthetic pathway in mice. The sequential enzymatic reactions are well-illustrated with consistent visual elements and directional flow. Each enzyme is properly labeled with both its gene ID and function, while metabolic intermediates are represented as circles connected by arrows that show the pathway progression. The cytosolic localization is appropriately indicated by the cell-like outline, providing biological context. The color coding differentiates enzymes from metabolites, and the legend provides additional clarification of all elements in the diagram. Font sizes are balanced for readability without overcrowding the image.","necessary_changes":null,"optional_changes":null}