Figure: 'de novo' UMP biosynthetic process (Mouse)¶
This figure illustrates the 'de novo' UMP biosynthetic process (GO:0044205) in mice. The pathway shows the stepwise conversion of carbamoyl-phosphate to UMP through multiple enzymatic reactions.
Three key enzymes are involved: 1) CAD (MGI:1916969) - A trifunctional enzyme with three catalytic activities: - Carbamoyl-phosphate synthase (CPS, GO:0004088) - Aspartate carbamoyltransferase (ATC, GO:0004070) - Dihydroorotase (DHO, GO:0004151)
2) DHODH (MGI:1928378) - Dihydroorotate dehydrogenase (GO:0004152), a mitochondrial enzyme that catalyzes the conversion of dihydroorotate to orotate.
3) UMPS (MGI:1298388) - A bifunctional enzyme with two activities: - Orotate phosphoribosyltransferase (OPRT, GO:0004588) - Orotidine-5'-phosphate decarboxylase (ODC, GO:0004590)
The pathway demonstrates sequential metabolic reactions (black arrows) as well as causal relationships between enzyme activities (red arrows). Metabolites are shown in light blue boxes while enzyme proteins are colored distinctively based on their function. The pathway operates primarily in the cytoplasm, with the DHODH reaction occurring at the mitochondrial membrane.
Feedback from AI on figure:
{"feedback":"This diagram effectively represents the 'de novo' UMP biosynthetic process in mice as described in the GO-CAM model. The illustration maintains a professional style suitable for scientific journals like Cell or Nature, using clear visual elements and an appropriate level of detail.\n\nStrengths of the diagram include:\n- Clear organization of the pathway showing the sequential flow of reactions\n- Distinct representation of the three key enzymes (CAD, DHODH, and UMPS) with their respective activities\n- Appropriate subcellular localization showing DHODH at the mitochondrial membrane\n- Effective use of color coding to distinguish different components\n- Comprehensive legend that explains all elements of the diagram\n- Improved pathway flow indicators showing the sequence of metabolite transformations\n- Uniform text sizing for better readability","necessary_changes":null,"optional_changes":null}