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Figure: 'de novo' XMP biosynthetic process (Mouse)

id: gomodel:60d5209a00001406

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This figure illustrates the 'de novo' XMP biosynthetic process in mouse, showing the sequential enzymatic reactions that occur in the cytosol. Each enzyme is color-coded and labeled with its gene name and MGI identifier. The pathway proceeds through 9 steps:

  1. PPAT (MGI:2387203) - amidophosphoribosyltransferase activity 2-3,5. GART (MGI:95654) - a trifunctional enzyme with phosphoribosylamine-glycine ligase, phosphoribosylglycinamide formyltransferase, and phosphoribosylformylglycinamidine cyclo-ligase activities
  2. PFAS (MGI:2684864) - phosphoribosylformylglycinamidine synthase activity 6-7. PAICS (MGI:1914304) - a bifunctional enzyme with phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase activities
  3. ADSL (MGI:103202) - (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase activity

The pathway then branches: 9a. ATIC (MGI:1351352) - bifunctional enzyme with phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase activities 9b. IMPDH1/2 (MGI:96567/109367) - IMP dehydrogenase activity

Both branches ultimately lead to the production of XMP (xanthosine monophosphate).

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the 'de novo' XMP biosynthetic process in mice with excellent clarity and organization suitable for publication in high-impact journals like Cell or Nature. The pathway flow is logically arranged from top to bottom within the cytosol, with each enzyme clearly labeled with both its name and MGI identifier. The color-coding system distinguishes different enzyme types, and numbered steps enhance the readability of the sequential process. The addition of substrate labels at branch points (AICAR and IMP) provides helpful context, and the final convergence to XMP is clearly visualized. The comprehensive legend explains the pathway components and enzyme functions, making this figure accessible to readers with varying levels of familiarity with the pathway.","necessary_changes":null,"optional_changes":null}