Figure: dTMP biosynthetic process1A (Mouse)¶
This diagram illustrates the dTMP biosynthetic process in mouse cells, showing the pathway occurring in the nucleus. The process begins with UDP being converted to dUDP by the ribonucleoside-diphosphate reductase (RNR) complex. Next, nucleoside diphosphate kinases (Nme1, Nme2, and Nme3) convert dUDP to dUTP. The dUTP is then converted to dUMP by dUTP diphosphatase (Dut). Finally, thymidylate synthase (Tyms) converts dUMP to dTMP. The diagram also shows regulatory roles of Shmt1/2 (glycine hydroxymethyltransferase) and Dhfr (dihydrofolate reductase) in the tetrahydrofolate cycle, which provide methyl groups essential for Tyms function.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the dTMP biosynthetic process in mice, accurately representing the pathway components and their relationships as described in the GO-CAM model. The diagram's strength lies in its clarity and organization, with well-defined enzyme boxes, metabolite circles, and directional arrows that guide the viewer through the process step by step. The inclusion of functional annotations for each enzyme enhances understanding of the specific role each protein plays in the pathway. The nucleus compartmentalization correctly depicts the cellular location specified in the GO-CAM data.","necessary_changes":null,"optional_changes":"Future versions could include folate cycle intermediates to provide more detail on how Shmt1/2 and Dhfr contribute to thymidylate synthesis, though this would add complexity and is not essential for understanding the core pathway."}