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Figure: UDP biosynthetic process (Mouse)

id: gomodel:60e7989d00000281

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The diagram illustrates the UDP biosynthetic pathway in mouse cells. The pathway begins with carbamoyl phosphate and proceeds through multiple enzymatic steps to produce UDP, which is critical for nucleotide metabolism.

Four key mouse gene products catalyze this process: 1. CAD - a multi-domain protein with three enzymatic activities: - Carbamoyl-phosphate synthase (creates carbamoyl phosphate) - Aspartate carbamoyltransferase (converts to carbamoyl-aspartate) - Dihydroorotase (forms dihydroorotate)

  1. DHODH (Dihydroorotate dehydrogenase) - converts dihydroorotate to orotate

  2. UMPS - a bifunctional enzyme with two activities:

  3. Orotate phosphoribosyltransferase (converts orotate to OMP)

  4. Orotidine-5'-phosphate decarboxylase (forms UMP from OMP)

  5. CMPK1 (UMP kinase) - catalyzes the final conversion of UMP to UDP

The entire process occurs in the cytoplasm and represents the de novo pyrimidine synthesis pathway, essential for nucleic acid production.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the UDP biosynthetic pathway in mice with excellent clarity and scientific accuracy. The pathway flow is logically arranged, with each enzyme and metabolite clearly labeled. The use of color coding for different gene products (CAD, DHODH, UMPS, and CMPK1) helps differentiate the enzymatic activities, and the increased font size improves readability. The repositioning of CAD's enzymatic activities has resolved the overlapping text issue, making all labels clearly legible. The addition of a comprehensive legend enhances understanding of the pathway components and their relationships. The cellular compartment indication and overall aesthetic design are appropriate for a scientific publication like Cell or Nature.","necessary_changes":null,"optional_changes":null}