Figure: GMP salvage 2a, from adenosine (Mouse)¶
This diagram illustrates the GMP (guanosine monophosphate) salvage pathway in mouse, showing how adenosine is converted to GMP through several enzymatic steps.
Key components: - Blue circles: Metabolites in the pathway (adenosine → inosine → hypoxanthine → IMP → XMP → GMP) - Pink rounded rectangles: Enzymes catalyzing each conversion - Ada (adenosine deaminase): Converts adenosine to inosine - Pnp (purine-nucleoside phosphorylase): Converts inosine to hypoxanthine - Hprt1 (hypoxanthine phosphoribosyltransferase): Converts hypoxanthine to IMP (inosine monophosphate) - Impdh1 and Impdh2 (IMP dehydrogenase): Convert IMP to XMP (xanthosine monophosphate) - Gmps (GMP synthase): Converts XMP to GMP
The entire process is part of GO:0032263 - GMP salvage, which recycles purines to maintain nucleotide pools in the cell.
Feedback from AI on figure:
{"feedback":"The diagram effectively visualizes the GMP salvage pathway in mouse, showing the conversion from adenosine to GMP through several enzymatic steps. The use of distinct colors for metabolites (blue circles) and enzymes (pink rounded rectangles) makes the components easy to identify. The directional arrows clearly indicate the reaction flow, and the dotted lines connecting enzymes to their respective reactions enhance understanding of the catalytic relationships. The addition of enzyme function labels provides valuable context about each protein's role in the pathway. The layout is clean and organized, making it suitable for publication in a scientific journal.","necessary_changes":null,"optional_changes":null}