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Figure: GMP salvage 2b, from adenosine (Mouse)

id: gomodel:60ff660000000897

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This figure illustrates the GMP salvage pathway in mouse, showing the enzymatic conversion of adenosine to GMP. The pathway consists of four main steps:

  1. Adenosine is phosphorylated to AMP by adenosine kinase (Adk, MGI:87930)
  2. AMP is deaminated to IMP by AMP deaminase enzymes (Ampd1/2/3, MGI:88015/88016/1096344)
  3. IMP is oxidized to XMP by IMP dehydrogenase enzymes (Impdh1/2, MGI:96567/109367)
  4. XMP is converted to GMP by GMP synthase (Gmps, MGI:2448526)

Each step requires specific cofactors: ATP for steps 1 and 4, NAD+ for step 3, and glutamine for step 4. The entire pathway is annotated as GMP salvage (GO:0032263), which allows the cell to recycle adenosine to produce GMP without requiring energy-intensive de novo synthesis. Metabolites are shown as blue hexagons, and enzymes as yellow-gradient rectangles with their MGI identifiers.

Feedback from AI on figure:

{"feedback":"This diagram effectively illustrates the GMP salvage pathway in mouse, showing the conversion of adenosine to GMP through several enzymatic steps. The use of distinct visual elements helps differentiate between metabolites (blue hexagons) and enzymes (yellow-gradient rectangles). The addition of cofactors along reaction arrows provides important biochemical context, and the MGI identifiers for each enzyme add scientific precision. The cellular background subtly suggests the biological context without overwhelming the diagram's clarity.","necessary_changes":null,"optional_changes":"The diagram balances scientific accuracy with visual appeal, making it suitable for publication in high-impact journals. The reaction descriptions and overview section enhance educational value by explaining the pathway's purpose."}