Figure: cobalamin metabolic process 1, adenosylation of cobalamin (Mouse)¶
The diagram illustrates the GO-CAM pathway for cobalamin metabolic process 1 (adenosylation of cobalamin) in mouse cells.
The pathway involves two main cellular compartments: - Cytosol (GO:0005829): Contains MMACHC with oxidoreductase and cyanocobalamin reductase activities, and MMADHC with molecular carrier activity - Mitochondrial Matrix (GO:0005759): Contains MMAB with corrinoid adenosyltransferase activity, MMAA with molecular carrier activity, and MMUT with methylmalonyl-CoA mutase activity
The process begins in the cytosol where MMACHC processes cobalamin and passes it to MMADHC. MMADHC then transports the processed cobalamin to the mitochondrial matrix where MMAB catalyzes adenosylation. MMAA interacts with cobamamide, which then allows MMUT to perform its enzymatic function leading to succinyl-CoA biosynthesis (GO:1901290).
The pathway diagram uses color coding to differentiate proteins and activities in different cellular compartments: blue shades for cytosolic components and red shades for mitochondrial components.
All components shown are directly from the GO-CAM model, with no inferred elements added.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the cobalamin metabolic process pathway, clearly showing the progression from cytosolic to mitochondrial activities. The color coding helps distinguish between compartments, and the addition of a legend greatly enhances understanding of the different elements. The layout is well-organized with logical flow and proper spacing between components. Font sizes are appropriate and protein names are properly emphasized in bold. The GO terms are correctly labeled, providing important context for the biological processes. This diagram successfully represents the GO-CAM pathway in a style suitable for publication in scientific journals.","necessary_changes":null,"optional_changes":null}