Figure: SP-ANN-SEC14L1¶
This diagram illustrates the molecular pathway described in the GO-CAM model (gomodel:613aae0000000011), showing how SEC14L1 regulates the RIG-I/MAVS signaling axis in human cells.
Key components: • RIG-I (O95786): A pattern recognition receptor (GO:0038187) located in the cytoplasm • MAVS (Q7Z434): A molecular adaptor (GO:0060090) located at the mitochondrial membrane that binds to RIG-I (GO:0039552) • SEC14L1 (Q92503): Exhibits protein sequestering activity (GO:0140311) that negatively regulates MAVS
The diagram shows that RIG-I in the cytoplasm binds to MAVS at the mitochondrial membrane, while SEC14L1 inhibits MAVS through its protein sequestering activity. MAVS functions as a molecular adaptor, continuing the signaling cascade.
All connections depicted are based on direct experimental evidence as documented in the GO-CAM model.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the SEC14L1-regulated RIG-I/MAVS signaling pathway in a clear, scientifically accurate manner suitable for publication in journals like Cell or Nature. The compartmentalization between cytoplasm and mitochondrial membrane is well-defined, and protein interactions are clearly depicted with appropriate arrows and symbols.\n\nKey strengths include:\n1. Clear visual differentiation between proteins using distinct shapes and colors\n2. Proper labeling of molecular functions with corresponding GO terms\n3. Accurate representation of subcellular localization\n4. Well-designed legend that explains all visual elements\n5. Semi-transparent white backgrounds behind text labels to ensure readability\n\nThe addition of white backgrounds behind all labels significantly improved readability, especially where text overlaps with cellular structures. The diagram's professional appearance is enhanced by the consistent use of fonts, appropriate spacing, and clean lines.","necessary_changes":null,"optional_changes":null}