Figure: cGAS-Sting pathway (Drosophila)¶
This diagram illustrates the cGAS-Sting antiviral signaling pathway in Drosophila melanogaster. The pathway begins with the detection of viral nucleic acids (DNA or dsRNA) by cGAS-like receptors cGlr1 and cGlr2. Upon activation, these receptors synthesize cyclic dinucleotides (3',2'-cGAMP and 2',3'-cGAMP respectively), which bind to and activate the Sting adaptor protein. Activated Sting then triggers the Rel transcription factor, which translocates to the nucleus to initiate transcription of antiviral genes, ultimately resulting in a defense response against viral infection. This pathway represents a crucial innate immune mechanism in Drosophila for combating viral pathogens.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the cGAS-Sting pathway in Drosophila with excellent scientific accuracy. The pathway flow is clearly represented, showing how viral nucleic acids activate cGlr1 and cGlr2 receptors, leading to cGAMP synthesis, Sting activation, and ultimately Rel-mediated transcription of antiviral genes. The addition of interaction labels on arrows enhances clarity, and the expanded legend provides comprehensive information about each component. The visual hierarchy and color scheme effectively differentiate between the various molecular components, creating a figure suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}