Figure: SP-ANN_TGM2¶
This figure illustrates the pathway for TGM2-mediated histone modification by serotonin and dopamine as described in the GO-CAM model SP-ANN_TGM2. The process occurs in four key steps:
Step 1: KPNA4 (O00629) functions as a nuclear import signal receptor at the nuclear pore (GO:0005643), facilitating the import of TGM2 into the nucleus.
Step 2: TGM2 (P21980) translocates to the nucleosome (GO:0000786) where it will perform enzymatic modifications.
Step 3a: TGM2 acts as a serotonyltransferase (GO:0120295), catalyzing the transfer of serotonin (5-HT, CHEBI:28790) to histone proteins in the nucleosome.
Step 3b: In parallel, TGM2 also functions as a dopaminyltransferase (GO:0120297), transferring dopamine (DA, CHEBI:18243) to histone proteins.
Step 4: Following serotonylation, histone H3C1 (P68431) engages in protein binding interactions (GO:0005515) within the nucleosome structure, potentially altering chromatin organization and gene expression.
Feedback from AI on figure:
{"feedback":"The figure effectively illustrates the TGM2-mediated histone modification pathway with excellent clarity and organization. The strategic use of color coding helps distinguish different molecular components, while the italicized labels for activities provide a clear visual distinction between entities and processes. The addition of numbered steps enhances the sequential understanding of the pathway.\n\nThe cellular compartmentalization is well-represented, showing the clear distinction between cytoplasmic and nuclear activities. The nuclear pore complex is appropriately positioned to demonstrate the import process. The comprehensive legend provides necessary context for both specialized and general audiences, explaining both the symbols and the biological significance of each step.\n\nThe spacing between elements has been improved to reduce clutter, and text is positioned to avoid overlap. The level of detail is appropriate for a scientific journal figure, providing sufficient information without overwhelming complexity.","necessary_changes":null,"optional_changes":null}