Figure: cobalamin transport 2, distribution to tissues (Mouse)¶
This figure illustrates the cobalamin (vitamin B12) transport pathway in mice, showing the key components involved in its distribution to tissues.
The process begins in the enterocyte (left cell), where cobalamin is transported out of the cell by the ABCC1 transporter (Abcc1, MGI:102676) located at the basal plasma membrane (GO:0009925). ABCC1 functions as an ABC-type vitamin B12 transporter (GO:0015420).
In the extracellular space (GO:0005615), the released cobalamin binds to transcobalamin II (TCN2, MGI:98534), forming a B12-TCN2 complex. TCN2 serves as a molecular carrier protein (GO:0140104) that enables transport of cobalamin through the bloodstream.
At the target cell (right), the CD320 receptor (Cd320, MGI:1860083) located on the plasma membrane (GO:0005886) recognizes and binds the TCN2-cobalamin complex. CD320 functions as a cargo receptor (GO:0038024) that specifically recognizes TCN2 as it binds to the external side of the plasma membrane (GO:0009897).
This entire process constitutes the cobalamin transport pathway (GO:0015889), which is essential for the distribution of vitamin B12 throughout the body.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the cobalamin transport pathway in mice with excellent clarity and scientific accuracy. The representation faithfully captures the GO-CAM model components, showing the relationship between ABCC1, TCN2, and CD320 proteins and their respective molecular functions. The visual hierarchy is clear, with appropriate use of color coding and consistent styling that enhances readability. Directional arrows effectively show the flow of transport and interactions between components. The inclusion of GO terms and MGI identifiers adds scientific rigor while maintaining visual appeal suitable for publication in high-tier journals.","necessary_changes":null,"optional_changes":null}