Figure: cobalamin metabolic process 3, methylation of cobalamin (Mouse)¶
This diagram illustrates the cobalamin metabolic process (GO:0009235) in mouse cells. The pathway shows the conversion of cob(II)alamin (CHEBI:16304) to methylcobalamin (CHEBI:28115) in the cytosol (GO:0005829) through a series of enzymatic reactions.
Four key mouse proteins are involved: - Mmachc (MGI:1914346): Functions as an oxidoreductase in the initial reduction step - Mmadhc (MGI:1923786): Provides molecular carrier activity for the transport step - Mtrr (MGI:1891037): Acts as a methionine synthase reductase - Mtr (MGI:894292): Functions as a methionine synthase in the final methylation step
The arrows indicate the direction of reactions with different colors representing: - Purple arrows: Reduction reactions - Blue arrows: Transport processes - Green arrows: Methylation reactions - Orange dashed arrows: Activation relationships between proteins
The diagram depicts the causal associations between proteins as described in the GO-CAM model, showing how each protein activity enables or catalyzes specific steps in the pathway.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the cobalamin metabolic process in mouse cells with a clean, publication-ready design. The pathway is clearly depicted with distinct proteins, their functions, and the directional flow of reactions. The color-coding of different reaction types (reduction, transport, methylation, activation) significantly enhances clarity and makes the diagram more intuitive to understand. The legend is comprehensive and helps viewers interpret all elements of the diagram. The layout effectively captures the relationships between proteins as described in the GO-CAM model, with appropriate labels for molecular components and their identifiers. The cellular context (cytosol) is clearly indicated, and the overall aesthetic is clean and professional, suitable for publication in high-quality scientific journals.","necessary_changes":null,"optional_changes":null}