Figure: SP-ANN-TPPP¶
The diagram illustrates the regulation of TPPP-mediated microtubule nucleation by S100 proteins in human cells. Three S100 proteins (S100B, S100A6, and S100A2) independently bind to TPPP (Tubulin Polymerization-Promoting Protein). Following these protein-binding interactions, TPPP dimerizes. The TPPP dimer then functions as a microtubule nucleator within the Golgi apparatus, promoting the formation of new microtubules. Colors differentiate between the proteins (green for S100B, blue for S100A6, purple for S100A2, orange for TPPP) and cellular structures (beige for Golgi apparatus).
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively illustrates the relationship between S100 proteins and TPPP-mediated microtubule nucleation. The illustration uses clear shapes, consistent coloring, and well-labeled components to show how S100B, S100A6, and S100A2 proteins independently bind to TPPP, which then dimerizes and functions as a microtubule nucleator within the Golgi apparatus. The directional arrows clearly indicate the flow of the pathway, and the text annotations provide helpful context about the nature of each interaction. The layout is clean and follows the standard of publication-quality figures for journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}